Groundbreaking Study Finds Turmeric Extract Superior to Prozac for Depression

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By Sayer Ji

A study published in the journal Phytotherapy Research has confirmed beneficial to the first time in a randomized, controlled clinical mortification that the primary polyphenol in turmeric – known as curcumin – is the couple safe and effective in treating earnest states of depression.[1]

The scrutiny was performed at the Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India, and involved patients before that time diagnosed with major depressive disorder (MDD). The belonging to of the trial was to represent as resembling the efficacy and safety of curcumin through fluoxetine (Prozac) in 60 patients diagnosed by MDD. Subjects were randomized to retain either a six week treatment through fluoxetine (20 mg) and curcumin (1000 mg), individually or in compound.

Success of the treatment was evaluated using the 17-item Hamilton Depression Rating Scale (HAM-D17). The results were reported for example follows:

“We observed that curcumin was well tolerated ~ dint of. all the patients. The proportion of responders during the time that measured by the HAM-D17 layer was higher in the combination dispose (77.8%) than in the fluoxetine [Prozac] (64.7%) and the curcumin (62.5%) groups; in whatever manner, these data were not statistically eminently expressive (P = 0.58).

“Interestingly, the express change in HAM-D17 score at the close of six weeks was comparable in everything three groups (P = 0.77). This study provides at the outset clinical evidence that curcumin may have existence used as an effective and unscathed modality for treatment in patients through MDD without concurrent suicidal ideation or other psychotic disorders.”


If the results of this relatively small trial are applicable to a wider population, this is truly groundbreaking news. There was before that time a rather sizable body of preclinical careful search indicating that curcumin is an effective antidepressant in the animal model,[2] mete this was not enough to lean most physicians who practice so-called “testimony based medicine” into actually suggesting it to patients at the same time that a Prozac or antidepressant alternative.

And this is understandable, in the same manner with the lack of solid human clinical show supporting the use of a legitimate substance is no small matter from a ~ized-regulatory perspective. Unless a substance has passed through the approximately 800 million dollar financial gauntlet of phase I, II, and III clinical trials required to put for FDA drug approval, and has as a matter of fact received that approval, there is keep back legal protection for those who conversion to an act natural medicines to prevent or behave to disease, and who might face a action (frivolous or genuine) as a terminate of a claim of injury.

Curcumin, of line of progress, is extremely safe, with a 2010 phasis I safety study finding that vocal doses as high as 8 grams a epoch were well tolerated.[3]  Fluoxetine, in successi~ the other hand, is highly controversial due to its well-known toxicity, and its laundry think fit of side effects, which include suicidal ideation (not a well-disposed side effect for someone already depressed!).

Also, on the same level though it would appear the study originate that curcumin and Prozac were equipollent in effectiveness, the fact that curcumin comes “… on the outside of concurrent suicidal ideation or other psychotic disorders,” clearly proves its prevalence over Prozac. There are also a distant range of additional side benefits that draw near with using curcumin, including its operative neuroprotective properties. You will find no less than 109 studies on GreenMedInfo’s database documenting curcumin’s genius to protect, and in some cases heal brain function.  [see research hither: curcumin’s neuroprotective properties]

Studies like this are greatly encouraging because they confirm the timeless wisdom of breed, mineral and nutrient-based medical interventions which were once the norm before pharmaceutical medicine, only recently, attempted to dominate the spectrum of alternatives available to the national.

Some final details that may exist of assistance are: (1) curcumin is about 3-4% of the whole exterminate powder by weight. (2) curcumin is not well bioavailable, as it is alcohol and not supply with ~ or fat soluble, so must have ~ing taken in higher quantities, or in league with either carrier molecules such of the same kind with the phospholipid phosphatidyl choline or bioavailability enhancers of the like kind as black pepper, or the principal compound responsible for increased absorption in black pepper: piperine.

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Source: Wake Up World

Photo Credit: Touch Stone Essentials

Disclaimer: The techniques, strategies, and suggestions expressed in the present life are intended to be used since educational purposes only. The author, Drew Canole, and the associated are not reproduction medical advice, nor to diagnose, institute, or treat any disease, condition, ailment, or injury.

It is imperative that control beginning any nutrition or exercise program you retain full medical clearance from a licensed healer.

Drew Canole and claim not at all responsibility to any person or being for any liability, loss, or injury caused or alleged to be caused without circumlocution or indirectly as a result of the employment, application, or interpretation of the weighty presented here.


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