Future of Medicine should not be Elysium

To desire a long and healthy life was and is a fancy of humankind since the inception of human civilization. Based on current pace, within 20-50 years healing science will achieve level where multiplied difficult to manage diseases, like cancers and some infectious diseases become easily treatable.

Most modern example is hepatitis C virus romance. Just 5 years ago, it seemed that in that place was no hope for people assuming by Hep C. There was none approved vaccine or approved drugs qualified of stopping this virus that causes expanded liver fibrosis. However now, if completely unexpectedly, we accept anti-viral medicine that show up to 99% effectiveness assessment (in some combination) and with not so much side effect (double benefit). No any could imagine this.

What about fresh success in cancer therapy? Treatments by patient’s own tumor-specific re-engineered T cells or by antibodies to awaken the body’s own immune system had achieved an novel level of success reaching up to 50% effectiveness asperse.

These are all amazing news as antidote to anyone and especially for individuals through these medical conditions. However, even allowing the future seems bright, there is a thing unsettling in all this. It is the value tag.

Costs are so prohibitively acute that almost 95% of world peopling would not able to afford it attached their own (for example, swelling immuno-therapy with the patient’s admit immune cells can cost more than 500,000$ , and Hep C manipulation can cost between 50,000 – 120,000$ per treatment ).

More worrisome is the deed that unlike small molecules used in accustomed pharmacology that can be easily manufactured in mass gradation with minimal investment as generics, many advanced new treatments now days are based put ~ large, complex molecules, called biologicals like humanized antibodies, or calm more complex procedures like harvesting and re-engineering patient’s allow T cells. These are completely unlike categories of medicine with no substantive way for mass scale production.

How can we afford this costly medicine to live longer and healthier?

Movie, Elysium, shows some such scenario. In this movie, the world are divided into super rich and everyone other. Super rich live on a huge man orbital station and are completely set ~ of any disease due to medicinal technologies. These medical technologies are unapproachable to regular earthly people.

In my belief, with the few rare exceptions, we complete not control our medical health trajectory. Hence, each human should have an inherent perpendicular to have an access to the most advanced medical technologies. However, no treaty or state budget can afford medical cost so high.

So what is the dis~? Of course, the solution is in technology excepting in different kind of technology that is in pupilage right now. It is gene therapy (gene silencing, cutting, replacing, modifying). Gene based medical technologies has sum of ~ units major advances over other type of biologicals: (a) gene therapy faculty of volition be much cheaper (everyone who worked with PCR or RT-PCR can make good that costs for primer nucleotides are custom cheap compared to antibodies), (b) gene therapy order treat the cause (genes) rather than result (proteins) of medical conditions.

Current remedial agent is based on repeated engagement by body’s proteins (receptors, cytokines, copying factors). Gene therapy will be based steady single or a few engagements with body’s DNA or RNA in quest of long-term effect (for example, using CRISPR-Cas9 theory). Such intervention can produce permanent fixes. An Overall require to be paid will be low and majority elect be able to afford it.

David Usharauli

Tension headaches customarily occur as a mild to moderate chafe which feels like a tight horde has been placed all around the commander tightened.

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