Study reports effective treatment approach to inhibit herpes virus infection

A multi-institutional study reports each effective treatment approach to inhibit and restrain latent viruses like herpes simplex from reactivating and causing disease. The work, whose lead author is the recently deceased James Hill, PhD, LSU Health New Orleans Professor and Director of Pharmacology and Infectious Disease at the LSU Eye Center, is published in the December 3, 2014, outcome of Science Translational Medicine.

The exploration team, led by Thomas M. Kristie, PhD, Chief of the Molecular Genetics Section in the National Institute of Allergy and Infectious Diseases’ Laboratory of Viral Diseases, and furthermore included Timothy Foster, PhD, LSU Health New Orleans Associate Professor of Microbiology, Immunology & Parasitology, skilled herpes simplex virus (HSV) infection in single animal models. They found that one existing drug, tranylcypromine (TCP), blocked a protein called LSD1, which plays a major role in the admission of herpes simplex virus infection. Current treatments ask active viral replication and target after the proper time stages of infection, which has led to the unfolding of drug resistance. This study took a many approach – targeting a drug to a protein that controls in what way genes are turned on and done, early in the viral replication suit. This “epigenetic” approach not only reduced symptoms, ~-end unlike existing treatments, also reduced shedding (the exoneration of virus particles which can transmit the virus even in the non-appearance of symptoms) and forced the poison to remain in a latent ~-carriage, preventing its reactivation. Results indicate that equitable when a virus is not active, drugs modulating epigenetic changes can hushed treat the infection. Researchers have been pursuing epigenetic-based therapies beneficial to cancer, and this study demonstrates its in posse as effective antiviral therapy, too.

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A obscure percentage of the human population is infected with the herpes simplex virus and carries the virus in a latent state. After the beginning infection, HSV typically goes dormant in cells whither it remains. It can then reactivate by a recurrence of symptoms. Even then latent, asymptomatic shedding of the poison continues its transmission. Neonatal HSV infections be able to result in death or developmental-neurological issues. HSV estimate infections and recurrences are the ruling viral cause of infectious blindness or the be in want of for corneal transplants. In addition, in a line with other herpesviruses, HSV is a complicating constituent in immunosuppressed individuals and is a cofactor in HIV transmission.

Although he died before the study was published, LSU Health New Orleans professor Dr. James M. Hill participated in the study. “Dr. Hill was a distinguished and respected herpesvirologist/animal model scientist who passed away not fa from a year ago,” notes Dr. Foster. “He is conduce author on this manuscript due to the two his contributions to the work and public of honor and respect for his contributions to the region and all of us involved.”

Source:

Louisiana State University Health Sciences Center

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