Bleomycin metabolism

This is a laconic post on pharmacology!

Bleomycin is inactivated ~ means of a cytosolic cysteine proteinase enzyme, Bleomycin hydrolase.

This enzyme is widely distributed in analogical tissues with the exception of the pelt and lungs, both targets of Bleomycin toxicity.

This is why, Bleomycin causes pulmonary fibrosis.

It’s likewise why bleomycin is used in derm cancers like squamous cell cancer.

That’s totality!


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