Matricellular proteins may be key therapeutic targets for common ocular disorders

A special issue ( of Journal of Ocular Pharmacology and Therapeutics highlights the latest scrutiny on matricellular proteins, which play a cavilling role in inflammation and blood tube formation in the eye and accordingly making them key targets for starting a~ therapies to treat common ocular disorders of that kind as glaucoma, dry eye disease, and time of life-related macular degeneration (AMD). Comprehensive survey articles and insightful editorials comprise this extraordinary issue of Journal of Ocular Pharmacology and Therapeutics, a pry-reviewed journal from Mary Ann Liebert, Inc., publishers (

The edition is available free on the Journal of Ocular Pharmacology and Therapeutics ( website till October 30, 2015. Guest Editor Dr. Sharmila Masli, Boston University (MA) has brought in company leading researchers and clinicians to contribute articles on a range of topics including the function of matricellular proteins and their role in perforation disease, the link between thrombospondin-1 (TSP-1), heat, and angiogenesis, and treatment approaches in unfolding that specifically target TSP-1.

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In the Review paper “Thrombospondin-1 and Pathogenesis of Age-Related Macular Degeneration (,” Michael Housset and Florian Sennlaub, Institut de la Vision, CNRS, and INSERM, Paris, France, propose that the rigidly decreased levels of TSP-1 in eyes canting by AMD implicate a central role on this account that TSP-1 in the development of the complaint.

Marielle Terzulli, Laura Contreras Ruiz, Abirami Kugadas, Sharmilla Masli, and Mihaela Gadjeva, Brigham and Women’s Hospital, Harvard Medical School, and Boston University, Boston, MA, analyzed the types and amounts of bacteria current in the eyes of mice that are TSP-1 insufficient and serve as a model conducive to the autoimmune disorder Sjögren’s syndrome. The goal of the investigation presented in the article “TSP-1 Deficiency Alters Ocular Microbiota: Implications despite Sjögren’s Syndrome Pathogenesis (” was to fix whether changes in the microbial peopling of the eye present a in posse new therapeutic target for intervening for the time of the early stages of the disorder.

“Dr. Masli has done a masterful work at ~s of bringing together the world‘s experts in matricellular biology of the eye in this special issue,” says Editor-in-Chief W. Daniel Stamer, PhD, Joseph A. C. Wadsworth Professor of Ophthalmology and Professor of Biomedical Engineering, Duke University, Durham, NC.


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