Pharmacology Tyroid and Antitiroid Hormon

 

$

)ntra*thyroidal synthesis and processing of thyroidal hormones

1.Iodide

is taken up at the basolateral small room membrane and transported to the apical membrane2.olypeptide bonds of

Tg (

thyroglobulin% are synthesized in the discordant endoplasmic reticulum and posttranslational modifications take grade in the /olgi$.0ewly formed

Tg

 is transported to the simplest organism surface in small apical esicles

(AV)

.ithin the follicular lumen

iodide

 is actiated and iodinates tyrosyl residues adhering

Tg

 producing fully

iodinated Tg

 containing

MIT, DIT, T

 and a molecular amount of

T!

 #organification and coupling% which is stored as colloid in the follicular lumen3.4pon

T”#

stimulation illi at the apical membrane engulf the colloid and endocytose the iodinated Tg to the degree that either colloid droplets

(CD)

 or insignificant esicles

(MPV)

5.6ysosomal proteolysis of the droplets or esicles hydrolyzes

 Tg

 to receipt in full its iodinated amino acids and carbohydrates

$.T

and

T!

 are released into the circulating medium

%.DIT

 and

MIT

 are deiodinated and the

 iodide

and

 tyrosine

are recycled

The bread chocolate cannot provide instead linked soundness plans.

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