Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg}

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Principles of pharmacology the pathophysiologic base of drug therapy 4th edition {prg}

P R IN C IP LES o f P H A R M A C O LO G Y
TH E P ATH O P H YS IO LO G IC B AS IS O F D R U G TH E R AP Y
F o u r t h E d ... David E. Golan, MD, PhD
Editor-in-Chief
Ehrin J. Armstrong, MD, MSc
April W. Armstrong, MD, MPH
Associate Editors
P R IN C... Acquisitions Editor: Matthew Hauber
Product Development Editor: John Larkin
Marketing Manager: Mike McMahon
Production Pro... To our students and the patients they will serve
 Contents
Preface ........................................................................................... ix
Preface to... viii Contents
21 Pharmacology o Volume Regulation ...........................358
Hakan R. Toka and Seth L. Alper
22 Pharma... Preface
pathophysiology, and pharmacology o the relevant sys-
tem. Sections throughout the book contain substantial
amount... This approach has several advantages. We anticipate that
students will use the text not only to learn pharmacology but
als... Molecular Pharmacology at Harvard Medical School and in
the Hematology Division at Brigham and Women’s Hospital
and the Da... Robert L. Barbieri, MD
Kate Macy Ladd Pro essor o
Obstetrics, Gynecology and
Reproductive Biology
Department o Obstetrics,... xvi Contributors
Nidhi Gera, PhD
Research Fellow
Department of Biological Chemistry
and Molecular Pharmacology
Harvard Med... Benjamin Leader, MD, PhD
Chie Executive O f cer
ReproSource
Woburn, Massachusetts
Jonathan Z. Li, MD, MMSc
Assistant Pro e... xviii Contributors
Charles N. Serhan, PhD
Simon Gelman Professor of
Anaesthesia (Biological Chemistry
and Molecular Pharma... xix Contributors
Victor W. Sung, MD
Associate Professor, Department of
Neurology, Division of Movement
Disorders
The Unive... I
Fundamental Principles of
Pharmacology
 ββ
γ
αα
BB C
2
GDDPPININTRTRODUCTION &CASE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2–33
CONFORMAT... C h a p t e r 1 Drug–Receptor Interactions 3
begin to interact with nearby amino acids in the polypeptide
chain. These int... 4 FUNDAMENTALPRINCIPLES OFPHARMACOLOGY
which occur between atoms with opposite charges, are
stronger than hydrogen bonds b... C h a p t e r 1 Drug–Receptor Interactions 5
Impact o Drug Binding on the Receptor
How does drug binding produce a biochem... 6 FUNDAMENTALPRINCIPLES OFPHARMACOLOGY
drug to the receptor stabilizes one or more o these con or-
mations. Quantitative m... C h a p t e r 1 Drug–Receptor Interactions 7
ion channels; (2) transmembrane receptors coupled to intra-
cellular G protei... 8 FUNDAMENTALPRINCIPLES OFPHARMACOLOGY
Specialized transmembrane channels regulate these pro-
cesses. The unctions o ion c... C h a p t e r 1 Drug–Receptor Interactions 9
cannot be reactivated or a number o milliseconds, even i
the membrane potenti... 10 FUNDAMENTALPRINCIPLES OFPHARMACOLOGY
be grouped into f ve major amilies—G-stimulatory (Gs),
G-inhibitory (Gi), Go, Gq, ... C h a p t e r 1 Drug–Receptor Interactions 11
some o the diverse tissue localizations and actions o the
-adrenergic recept... 12 FUNDAMENTALPRINCIPLES OFPHARMACOLOGY
serine/threonine kinases (see Intracellular Receptors below),
drugs selective or r... C h a p t e r 1 Drug–Receptor Interactions 13
and its success has led to the development o a number o
drugs that act by si... Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} Principles of pharmacology the pathophysiologic basis of drug therapy 4th edition {prg} <img class="slide_image" src="http://www.slideshare.net/HanifAnjumHafizabad/principles-of-pharmacology-the-pathophysiologic-basis-of-drug-therapy-4th-edition-prg" data-small="http://image.slidesharecdn.com/principlesofpharmacologythepathophysiologicbasisofdrugtherapy4theditionprg-160306135852/85/principles-of-pharmacology-the-pathophysiologic-basis-of-drug-therapy-4th-edition-prg-64-320.jpg?cb=1457272825" data-normal="http://image.slidesharecdn.com/principlesofpharmacologythepathophysiologicbasisofdrugtherapy4theditionprg-160306135852/95/principles-of-pharmacology-the-pathophysiologic-basis-of-drug-therapy-4th-edition-prg-64-638.jpg?cb=1457272825" data-full="http://image.slidesharecdn.com/principlesofpharmacologythepathophysiologicbasisofdru

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