A new kind of antipsychotic

Antipsychotics are dopamine inhibiting agents that are used to quiet psychotic symptoms but there are a digit of downsides with this medication and these are: Antipsychotics motive brain damage (1), physical dependence (2), somnolence, slowness, weight gain, they increase your chances of developing diabetes, in profoundly doses can cause Parkinsonian sidepersonal estate and can produce involuntary movements of the assurance and rarely, of the arms and legs. (3) A dopamine reuptake inhibitor would effectively put in relief psychotic symptoms and wouldn’t motive these side effects. The mechanism toward this will be explained here.

The plan of conduct antipsychotics work is by blocking the D2 dopamine receptor up~ the post-synaptic neuron with a indivisible particle of the drug. This then ways and ~ that dopamine cannot enter the mercury-synaptic neuron and it is this which causes a reduction of psychotic symptoms. The intuitional faculty that dopamine does not simply circulate to other neurons is because the antipsychotic is blocking total the other D2 receptors in the region of the brain that is ready.

The way a dopamine reuptake inhibitor works is end blocking the receptors of pre-synaptic organic unit so that there is more dopamine in the synapse causing the postman-synaptic cell to be stimulated in the place of longer. The way this will ease psychotic symptoms is by concentrating dopamine in united area of the brain for at the same time that long as the drug is active. This means that dopamine will not ‘jump’ from one side of to the other to other groups of cells, a thing which corresponds to skittish behaviour and judgment.

The additional benefit of using dopamine reuptake inhibitors because an antipsychotic is that it assists the agitation in of as it allows focussing ~ward one particular area. This will be useful both in brain injury reinvigoration where the re-learning everyday tasks takes place and in cognitive behavioural therapy whither ways of thinking and behaving are re-learnt.

There are though two drawbacks in the use of dopamine reuptake inhibitors. When dexamphetamine is used to delight ADD/ADHD it causes appetite disadvantage which then stunts growth. (6) The other deficiency is that although dopamine reuptake inhibitors render not cause physical dependence some, of that kind as dexamphetamine, are psychologically addictive.

There is in like manner some precedent for the use of dopamine reuptake inhibitors in treating ideal disorders, although not psychosis explicitly. Attention Deficit Disorder and Attention Deficit Hyperactivity Disorder are popularly treated with Dexamphetamine and Lisdexamphetamine, the prodrug variant of Dexamphetamine. Also in 1937 the American Medical Association approved Amphetamine in the form of a Bensedrine Sulphate tablet to treat narcolepsy, postencephalitic Parkinsonism and inconsiderable depression. (6)

http://mattdiamand.blogspot.co.uk/2016/03/antipsychotics-lead to-brain-damage.html



http://www.uptodate.com/matters treated/first-generation-antipsychotic-medications-pharmacology-executive department -and-comparative-sideeffects

http://www.webmd.com/sum up-adhd/childhood-adhd/adhd-medications-and-infant-growth


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