Reduced activity of an important enzyme identified among suicidal patients

GRAND RAPIDS, Mich. – LIVING -It is known that family who have attempted suicide have ongoing excitement in their blood and spinal fluid. Now, a collaborative study from exploration teams in the U.S., Sweden and Australia  published in Translational Psychiatry shows that suicidal patients regard a reduced activity of an enzyme that regulates setting on fire and its byproducts.

The study is the come of a longstanding partnership between the study teams of Professor Sophie Erhardt, Karolinska Institutet  Professor Lena Brundin at Van Andel Research Institutein Grand Rapids, Michigan, and Professor Gilles Guillemin at Macquarie University in Australia. The overall object of the research is to discovery ways to identify suicidal patients.

Biological factors

Currently, there are no biomarkers for psychiatric complaint, namely biological factors that can be measured and provide information about the patient’s psychiatric hale condition. If a simple blood test can identify individuals at risk of seizing their lives, that would be a herculean step forward, said Erhardt, a Professor at the Department of Physiology and Pharmacology at the Karolinska Institutet, who led the toil along with Brundin.

The researchers analyzed certain metabolites, byproducts formed during infection and inflammation, in the blood and cerebrospinal liquid from patients who tried to take their avow lives. Previously it has been shown that so patients have ongoing inflammation in the descendants and cerebrospinal fluid. This new moil has succeeded in showing that patients who be favored with attempted suicide have reduced activity of ~y enzyme called ACMSD, which regulates inflammation and its byproducts.

“We think to be true that people who have reduced sprightliness of the enzyme are especially capable of being wounded to developing depression and suicidal tendencies whenever they suffer from various infections or excitement. We also believe that inflammation is convenient to easily become chronic in clan with impaired activity of ACMSD,” related Brundin.

Important balance

The substance that the enzyme ACMSD produces, picolinic pricking, is greatly reduced in both plasma and in the spinal liquid and gaseous of suicidal patients. Another product, called quinolinic pricking, is increased. Quinolinic acid is inflammatory and binds to and activates glutamate receptors in the brain. Normally, ACMSD produces picolinic pricking at the expense of quinolinic pricking, thus maintaining an important balance.

“We at this moment want to find out if these changes are barely seen in individuals with suicidal thoughts or suppose that patients with severe depression also express this. We also want to make known drugs that might activate the enzyme ACMSD and to this degree restore the balance between quinolinic and picolinic acid,” Erhardt said.

The study was funded with the support of the Swedish Research Council, Region Skåne and Central ALF funds. Additional assist came from National Institute of Mental Health (NIMH), the American Foundation toward Suicide Prevention, Van Andel Research Institute, Rocky Mountain MIRECC, the Merit Review CSR & D and the Joint Institute with regard to Food Safety and Applied Nutrition (University of Maryland), and the Australian Research Council. Several of the researchers wish indicated that they have business interests, which are recognized in the article.

Publication

“An enzyme in the kynurenine way that governs vulnerability to suicidal air by regulating excitotoxicity and neuroinflammation”

Lena Brundin, Carl M. Sellgren, Chai K. Lim, Jamie Grit, Erik Palsson, Mikael Landen, Martin Samuelsson, Christina Lundgren, Patrik Brundin, Dietmar Fuchs, Teodor T. Postolache, Lil Träskman-Bendz, Gilles J. Guillemin, Sophie Erhardt.

Translational Psychiatry, published online August 2, 2016, doi: 10.1038 / TP.2016.133.

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