VITAMIN K

♈️Vitamin K is in such a manner named as it was originally called Koagulationsvitamin.

♈️The material substance stores about 1 week’s fill of vitamin K.

♈️Vitamin K is a heavy-soluble vitamin

♈️ Vitamin K is required in favor of the synthesis of six factors in the clotting cateract : factors II, VII, IX, X and the anticoagulants protein C and protein S.

♈️ γ -Carboxylation of these factors is carried completely by the vitamin K-dependent carboxylase. This reverse action subsequently allows calcium binding and the conformational modify required to become active. The reverse action involves the oxidation of vitamin K. Warfarin works ~ dint of. stopping the reversal of this oxidation.

♈️ Bile is required on the side of absorption of vitamin K in the intestine.

♈️ Menadiol, a synthesized con~ation of vitamin K (K3), is furnish with ~-soluble and therefore can be absorbed in terms in which bile secretion is vile. But, it is not recommended in favor of use in neonates as it may draw out haemolysis.

♈️ Haemorrhagic disease of the newborn is caused ~ dint of. a relative vitamin K deficiency.

♈️ Prophylaxis to counter-poise haemorrhagic disease of the newborn is usually given at lineage as an injection of the naturally occurring fat-soluble phytomenadione.

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