Post-Doctoral position in Medicinal Chemistry (Fragment based Drug Discovery) (h/f)

Department : R&D
Reference : PDMC310816
Date : 01/09/2016
Place : Suresnes


Training date (18 months) in Suresnes (Paris)

SERVIER is France’s 2nd pharmaceutical cluster employing 21 000 people worldwide, and has achieved a consolidated turnover of € 4.2 billion, 91% comes from our international operations and is reinvested each year, 27% in investigation and development of new molecules. Servier is well known because its attention to the wellbeing of the cudgel, with particular importance placed on course of action evolution within the Group, and to every agreeable and productive working environment.


The overall goal of this set-doctoral project is to optimize new fragments (small and simple substructures of deaden with narcotics-like compounds) into potent and bioactive inhibitors. The exploration program will focus on the combination and study of Structure-Activity Relationships of renovated families of molecules derived from a “scrap” approach. The Fragment-based Drug Discovery is a commencing drug discovery paradigm developed by the pharmaceutical sedulousness to try to reduce the traduce of attrition of drug candidates ~ the agency of producing more effective molecules. In constant exercise, this approach is an alternative to rule high-throughput screening (HTS) when it is not feasible to identify drug-like molecules to a given target.

The conduct of the mission bequeath focus on several aspects:

• propose strategies concerning the synthesis and recovery of elucidation intermediates

• design and potent syntheses of molecules targeting key interactions through the anchor points of the alert biological site of interest

• multi-disciplinary interactions (Molecular Modeling, Structural Biology, Pharmacology…)

Keywords: Organic Chemistry, Medicinal Chemistry, Fragment-based Drug Discovery


Expected Skills:

Applicants should be under the necessity a PhD in organic chemistry. Proven expertise in synthetic systematized chemistry and medicinal chemistry is volatile. Knowledge and skills in Fragment-based Drug Discovery would subsist appreciated.

The candidates need to be self-motivated, rigorous and organized and fustiness have the ability to work considered in the state of part of a team and be seized of excellent written and oral communication skills. Good acting level of French would be appreciated.

Please inflict application (cover letter, cv, list of publications)


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