The Stage Is Being Set For An Anti-Aging Pill

America First is the public appeal of the day. But the US may failure to second place in the late quest to adopt an anti-aging pill.

Another regime modify – Americans have endured a scarcely any of them.  But has a single one new administration in Washington DC made unruffled a dent in the relentless greaten in the cost of medical care?

Out of a whole annual 2015 Gross Domestic Product (GDP) of $18.36 trillion, freedom from disease care costs amounted to $3.2 trillion (17.4%).  [] Health care used to have ~ing counted on the expense side sooner than the income side of the accounting ledger, a be drawn along on the economy.  But it being so that it is considered a source of American jobs that cannot exist shipped overseas like manufacturing jobs.  Politicians like to brag in what plight much money is being spent forward health care and divvy out taken in the character of much as they can to get votes.

However, if the newly installed control in Washington DC does in event lower the cost of medical care, won’t that accompany about a loss of jobs, beloved incomes the new President promised disillusioned Americans?

The jobs vs. parcel dilemma

The Department of Labor is counting soundness care related jobs to be the fastest growing source of jobs over the next decade.  [Bureau Labor Standards] The increased desire to obtain for doctors, nurses and ancillary personnel springs from a extending population of longer-living elderly Americans by chronic age-related diseases.  Of the roughly 150,000 the masses who die in the world one and the other day, ~100,000 die of old ~-related causes.   [Disabled World]

The commencing paradigm: conquer aging to reduce healthcare costs

There is opportunity to subject all age-related maladies in unit fell swoop as it has change to evident that there is a public genetic pathway for age-related diseases. [Aging Cell Oct 2015] Instead of excitement 5-10 different drugs to gratification the symptoms of aging as they occur, aging itself and its accompanying diseases would have ~ing delayed or even reversed, possibly ~ dint of. a single pill.

While gene mutations barely account for ~2% of all infirmity, most chronic age-related disease doesn’t unite faults in gene structure but in preference the dynamic ability of genes to form proteins (called gene expression or gene silencing) what one. is referred to as epigenetics.  [Age Oct 2013]

Therefore, inherited gene mutations may have existence inevitable and produce single-gene disorders in the same state as cystic fibrosis, sickle cell, herculean dystrophy or Huntington’s disease.  But aging and its accompanying diseases (diabetes, arthritis, cancer, organ of circulation, brain and liver disease) are modifiable.

The diet, namely a calorie-restricted diet, practiced daily or intermittently, doubles the lifespan and healthspan of bring down forms of life (fruit flies, roundworms, and mice).  Or a molecular mimic (i.e. anti-aging pill) may mark the same genes as food loss and provide a shortcut to hush the ravages of aging.

Anti-aging pill demonstrated in the dumb creature lab

Is this actually possible?  In each overlooked study published in 2008 researchers compared a calorie restricted diet to a ordinary diet + the red wine molecule resveratrol or resveratrol + other little antioxidant molecules in laboratory mice.  Mice bear about the same number of genes (~25,000) in the same proportion that humans.

Life-long calorie restriction in a peer activates ~832 genes.   In a short-term 12-week study, the calorie-restricted diet significantly differentiated the exercise of 198 genes and presumably would be the subject of altered 832 genes if practiced athwart a lifetime; plain resveratrol altered 225 genes and strikingly the resveratrol + other antioxidants (Longevinex®) 1711 genes.  [Experimental Gerontology Sept 2008]

In other words, what would taken a lifetime to perform in a laboratory mouse was exceeded ~ means of 9-fold in just 12 weeks.  Eighty-couple percent (82%) of the same 832 longevity genes were switched in the same lead (on or off) as a limited calorie diet ~ the agency of the resveratrol matrix (Longevinex®), which is a commercially useful nutraceutical.  That is the closest anyone has come to a molecular mimic of a calorie-restricted diet.

The civil stage is set for an anti-aging pill

The ~house is now set for the introduction of an anti-aging pill in the same proportion that President Donald Trump is considering Jim O’Neill, of libertarian belief, as head of the Food & Drug Administration.

O’Neill espouses the exemplar of drug companies proving their drugs are strong box and letting the consumers decide suppose that they are effective, thus reducing the require to be paid of drug development and the time it takes on the side of medications to reach the marketplace.  He is too an advocate of an anti-aging pill.  O’Neill sees it for example the world’s first trillion-dollar result

O’Neill sees a day whereas drug prices are driven lower ~ means of competition.  [Bloomberg News Dec 7, 2016]

President Trump wants to simple fellow all the drugs purchased under Medicare disclosed for bid, something Congress hasn’t had the skill to do.  [Bloomberg News Jan 12, 2017]  The pharmaceutical sector of the house market plunged just on the intention of such a development.

But O’Neill represents a revolutionary re-superscription of healthcare as we know it, not merited more competitively priced medicines.  O’Neill says: “Because in that place is not a free market in hale condition care, people are suffering very weighty health consequences.”

O’Neill wants to compel a halt to the idea America be possible to run in two directions at the sort time — produce new jobs in the healthcare sector time reducing the demand for care on the subject of which these jobs depend.

O’Neill has reported he believes anti-aging treatments “are lengthy overdue for innovation.”  He is setting the halting-place for an anti-aging pill.  [Bloomberg News Dec 7, 2016]

Modern remedy loathes a pill that would re-establish most modern medicines (antidepressants, anti-diabetic medicines, descent pressure pills, statin drugs, etc.).  The complete system of modern medicine is designed to entertainment disease as it occurs, not preclude or delay the onset of ail altogether.  There is no insurance billing code for “premature aging.”

Society pays the price for not adopting anti-aging strategies

Modern companionship is paying a steep price ~ means of not pushing an anti-aging pill progressive.  The care of millions of somewhat old Americans is breaking federal and individual budgets.  Medicare today is funding share of its financial obligations to retirees used up of the general fund that has merged through the Medicare and Social Security Trust funds.  The Medicare Trust Fund has no quantity but IOUs in it (promises to pay from the US direction called US Treasury notes).

As ~y aside, the reason why immigrants obtain been allowed to cross our south border so freely has been to fabricate a larger group of young workers who prepare FICA payroll deductions to offset the extending costs of caring for aged Americans.

Furthermore, we be obliged gone past the point where a single one new drug can head off a looming mental health catastrophe as millions of Americans live long enough to drift into senility, dementia and Alzheimer’s memory loss.  Only 1 of 244 synthetic drugs as being Alzheimer’s disease gained approval from the FDA athwart the past decades.  [Biotech Now 2016]  Modern pharmacology has had its jeopardy and has abjectly failed.  Nutraceuticals like resveratrol pills be bound to be given an opportunity to pall this void.

Society must employ the most judicious available evidence today rather than wait a different decade for yet another disappointing synthetic medicine.  There is a growing material substance of evidence for the use of vitamin B1 (thiamin) and resveratrol to sluggish or even reverse brain aging.  [Knowledge of Health July 8, 2013; Lew Rockwell July 17, 2006]  These sum of ~ units molecules are currently found in ~y available nutraceutical (Longevinex® Advantage), formulated ~ the agency of this author.

Aging researcher S. Jay Olshansky says the goal of an anti-aging pill would be to stave off the onset of age-related ail by ~7 years and thus raw-boned Medicare from financial insolvency.  [Aging Today 2013] Alzheimer’s things being so costs Medicare/Medicaid $160 billion a year and some additional $46 billion in out-of-endure costs. [Alzheimer’s Association] Humanity cannot support NOT to push an anti-aging pill foster.

Natural molecules like resveratrol out-bring to pass pharmaceutically designed single gene-targeted drugs for the cause that they aim at a broad numeral of genes which is what would be required to slow or reverse aging.  [Annals New York Academy Sciences Aug 2015] Modern physic has negatively characterized resveratrol as a “confused molecule” that has no defined gene target.

Over a decade ago The Rand Corporation account tank placed an anti-aging pill in future Medicare budgets.  That proposal has been forgotten.  The enigma in adopting an anti-aging pill is not the learning, it’s the opposition to it.  Congress indispensably to help amortize pharmaceutical investments in existing deaden with narcotics technologies with tax credits in prescription to accelerate adoption of an anti-aging pill.

Did a part foretell the future of anti-aging pills?

In 1995 contriver Scott Van De Mark wrote a novel entitled ELIXIR (out of print), what one. was about a biologist who invented a bloom pill.  The novel wasn’t in the same manner much about the pill but the very large opposition to it.

In the volume, Dan McEllis, the name of the fictional scientist who developed the pill, won a Nobel Prize, acquired a put ~s into company to market his pill, became a billionaire, and had millions of Americans vexation his youth pill for $199 a month.

But this fictional scientist too had his product banned by the Catholic Church, initially opponent by the American Medical Association and peopling control groups, temporarily removed from auction by the Food & Drug Administration, and faced a Constitutional Amendment for it.

In the book, casket makers aligned through owners of cemeteries in an make trial to buy McEllis out, claiming so a pill would put many not at home of work.  Racial groups threatened inventor McEllis they would go public through accusations he was a racist allowing that he didn’t provide Blacks by some of the first pills.

Go to workhouse card for anti-aging nutraceutical companies

Today any nutraceutical company that dares to frame a claim its product has anti-aging properties faces wicked prosecution by the US Attorney General and the AG has pressed bankers to arbitrarily declare to be untrue applications for merchant accounts for any company that dares to market in the same state a product online. [ 2016]

Would the President himself take such a pill?

In Van de Mark’s part, doctors were eventually won over through McEllis when his youth pill had to subsist acquired exclusively by prescription only and they were divide in on the profits.  At primitive, doctors used up all the profitable pills for themselves and their families.  In the main division it was rumored the President of the United States was anger Elixir.  [Knowledge of Health 2010]

Imagine the impinging of an anti-aging pill

Jobs determine surely be lost with a $1 trillion resolution in healthcare costs.  Budget-way, the imagined reduction of $1 trillion of soundness care expenses made possible by acceptance of a theoretical anti-aging pill would absolutely free up funds to be used in other sectors of the economy.  It would create jobs in renovated areas like green energy, sustainable farming, etc.  Maybe even more consumer movables would be sold as discretionary gains increases.

Governments are likely to have existence hesitant to take timely action.  The society has also been wary of of the like kind a pill, concerned they would survive their retirement funds and live greater quantity years in a debilitated state through chronic disease, drooling at the orifice and confined to a wheel chair.  However, that is precisely the predicament we find most institutionalized senior Americans today – excessively-drugged and senile.  A trustworthy anti-aging pill prolongs healthspan of the same kind with well as lifespan.

The public destitution not wait for physicians and gatekeepers to include an anti-aging pill.  But the of the whole not private has been reticent to step pert without doctor approval and insurance repayment, both which are unlikely to occur.

U.S. may not have existence the first to adopt an anti-aging pill

Certainly the wine intemperate habits French and Italians adopted an anti-aging pill of sorts lengthy ago in liquid form.

A long-term 9-year study among elderly residents in Italy recently showed temper wine drinkers were half as convenient to experience mental decline compared to teetotalers.  But that finding was buried and researchers portrayed resveratrol in wine to the degree that an ineffective anti-aging agent. [ Dec 29, 2014]

The written consideration of Luigi Cornaro (1464-1566 AD) who lived in Padua, Italy and prolonged his life by limiting his food intake to 12 ounces and wine to 14 ounces a appointed time is often cited.  He died in a rocking professorship after living 102 healthy years.  [The Art of Living Long]  Red wine for the period of Cornaro’s time was unfiltered and granted 30 times more resveratrol and other anti-aging molecules.  It was on the same level more powerful than today’s red wine pills.

The newly elected conduct in Washington DC wants to prepare America first.  But it may not exist the first to adopt an anti-aging pill.

Short of placing resveratrol in stopple water, a foreign country (whose identity command remain undisclosed) is in negotiation to make provision such a pill for its complete adult population.  The pill was levy to a subjective test among regulation officials.  The aforementioned nutraceutical was pristine given to a general in the martial who was battling liver cancer.  Within a inadequate time his cancer markers fell into the according to rule range.  The second person given the pill had cataracts and instructed markedly improved vision within nine days. They feel it as a miracle pill.

Here in the US every anti-aging pill is covertly shunned.  Not just a single study to ascertain resveratrol’s readiness to reduce mortality from coronary artery disorder has taken place even though resveratrol is widely known being of the kind which a red wine molecule responsible beneficial to the French Paradox (the fact the red wine-intemperate habits French have a much lower decease rate than North Americans). Any researcher who significantly advances resveratrol knowledge may be falsely accused of examination fraud.  [ Sept 25, 2013; Oct 19, 2015] Overseas they haven’t built in the same state a strong medical industry to oppose it.

If in that place is going to be real make different in healthcare, an anti-aging pill should ascend on the list of priorities.  America cannot simultaneously advance in two opposite directions: (1) to rely concerning a continual supply of chronically calamity older Americans to provide new jobs; and (2) to make trial to prevent or delay age-kindred maladies to prolong healthspan and lifespan.  One highway must be chosen.

Despite a diet sweet in carbohydrates and sugars, longer life abeyance in America is now being achieved ~ dint of. adding years to the end of life rather than lowering infant mortality, as was the case a century ago.  The cost of care for a burgeoning peopling of older Americans will be crippling.

A calorie-restricted diet has been base to be effective even when implemented in older mammals.  [Rejuvenation Research 2004] The conjecture is no one is too crafty to benefit from an anti-aging pill that serves in the manner that a molecular mimic of a calorie restricted diet.

But so a pill must be affordable moreover.  The US Census Bureau projects there will be 54 million Americans a hundred years 65 years and over by the year 2020.  [Census Bureau] A $1/twenty-four hours anti-aging nutraceutical adopted into the diurnal health regimen by 54 million adult Americans would cost ~$20 billion a year.  That would exist far short of the pharmaceutical inquiry to develop the world’s elementary $1 trillion synthetic anti-aging unsalable article.   Come to think of it, one anti-aging pill that generates $1 trillion in revenues puts America up~ back where it started financially.  ©2017 Bill Sardi, Resveratrol

The Quest on the side of Immortality: Science at the Frontiers of Aging

The anti-aging pill

Biology of Human Aging (2nd Edition)

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