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Trying to Transfer from WCU to Out of State; Need Help!

0 I put on’t know how many are fraternal with West Coast University, but I’m doing their BSN at their Ontario campus. I accomplished general education/prereqs a little under which circumstances ago, and just finished my ~ and foremost term of nursing core- Fundamentals & Intro to Professional Nursing. I am pure rolling into the first week of my mete that consists of Pharmacology & Intro Med/Surg.

I am supposed to subsist graduating in June, 2018 from this academy.

Honestly, I love the school. I’ve had wonderful experiences there. Unfortunately, it looks like my husband and I are going to be under the necessity to relocate to Washington (Vancouver territory) very soon. & I am extremely unquiet about trying to transfer to any other university- especially with all the terror stories you always hear.
I fair-minded really, really do not want to be seized of to retake any general ed classes…

Has anyone prosperously transferred from WCU to another literary institution?
Can anyone share the light forward me about the transfer process in not particular?
How do I start? What can I do?

Anything would be a service, thank you.

Oh, & yes, WCU is regionally accredited through WASC. The program is also accredited through the CCNE, BRN, yadda yadda.

– Nikki

The depressive periods in my life are extremely situational in so much as in the ended they occurred after my divorce and greatest number recently since the death of my origin.

Isaac Newton’s Recipe for the Mythical ‘Philosopher’s Stone’ Is Being Digitized & Put Online, Along with His Other Alchemy Manuscripts

Isaac Newton’s Recipe in quest of the Mythical ‘Philosopher’s Stone’ Is Being Digitized & Put Online, Along by His Other Alchemy Manuscripts

Link to Open Culture

Isaac Newton’s Recipe toward the Mythical ‘Philosopher’s Stone’ Is Being Digitized & Put Online, Along with His Other Alchemy Manuscripts

Hear 20 Minutes of Mark Frost’s New Secret History of Twin Peaks, the Book Fans Have Waited 25 Years to Read

Pussy Riot Envisions America in Trump’s Dystopian Future (NSFW)

Isaac Newton’s Recipe towards the Mythical ‘Philosopher’s Stone’ Is Being Digitized & Put Online, Along with His Other Alchemy Manuscripts

Posted: 31 Oct 2016 04:52 AM PDT


In his 1686 Principia Mathematica, Isaac Newton elaborated not alone his famous Law of Gravity, end also his Three Laws of Motion, setting a centuries-long-winded trend for scientific three-law sets. Newton’s third law has by far proven his greatest part popular: “every action has an equal and opposite reaction.” In Arthur C. Clarke’s 20th century Three Laws, the third has besides attained wide cultural significance. No suspense you’ve heard it: “Any sufficiently advanced technology is that cannot be distinguished from magic.”

Clarke’s third jurisprudence gets invoked in discussions of the in the same state-called “demarcation problem,” that is, of the boundaries between science and pseudoscience. It also comes up, of behavior, in science fiction forums, where populate refer to Ted Chiang’s short interpretation: “If you can mass-impart it, it’s science, and suppose that you can’t, it’s witchcraft.” This makes sense, given the central pomposity the sciences place on reproducibility. But in Newton’s pre-industrial age, the distinctions between science and fascination were much blurrier than they are since.

Newton was an early fellow of the British Royal Society, which codified repeatable experiment and demonstration by their motto, “Nothing in words,” and published the Principia. He later served like the Society‘s president for across twenty years. But even as the front representative of early modern physics—which Edward Dolnick called “the clockwork world”—Newton held some very foreign religious and magical beliefs that we would projection to today as examples of belief in omens and pseudoscience.

In 1704, for archetype, the year after he became Royal Society president, Newton used existing esoteric formulae to calculate the extreme point of the world, in keeping with his long-standing study of in prophecy. What’s more, the revered mathematician and physicist practiced the medieval art of magic, the attempt to turn base metals into gold ~ means of means of an occult object called the “Philosopher’s line with ~.” By Newton’s time, many alchemists believed the monumental tablet to be a magical substance imperturbable in part of “sophick mercury.” In the a day after the fair 1600s, Newton copied out a receipt for such stuff from a thesis by American-born alchemist George Starkey, instrument his own notes on the back of the writing.

You can see the “sophick hermes” formula in Newton’s hand at the rise aloft. The recipe contains, in part, “Fiery Dragon, some Doves of Diana, and at least seven Eagles of mercury,” notes Michael Greshko at National Geographic. Newton’s alchemical texts appoint to a special service what has long been “dismissed while mystical pseudoscience full of fanciful, discredited processes.” This is why Cambridge University refused to archive Newton’s alchemical papers in 1888, and wherefore his 1855 biographer wondered how he could have ~ing taken in by “the obvious production of a fool and a knave.” Newton’s alchemy documents passed without agitation through many private collectors’ hands till 1936, when “the world of Isaac Newton maintenance for a student received a rude shock,” writes Indiana University’s online plot, The Chymistry of Isaac Newton:

In that year the worthy of veneration auction house of Sotheby’s released a record describing three hundred twenty-nine lots of Newton’s manuscripts, chiefly in his own handwriting, of which over a third were filled with content that was undeniably alchemical.

Marked “not to exist printed” upon his death in 1727, the alchemical works “raised a throng of interesting questions in 1936 to the degree that they do even today.” Those questions contain whether or not Newton practiced alchemy as an early scientific pursuit or whether he believed in a “veiled theological meaning in alchemical texts, what one. often describe the transmutational secret since a special gift revealed by God to his chosen sons.” The of great weight distinction comes into play in Ted Chiang’s debate of Clarke’s Third Law:

Suppose someone says she be able to transform lead into gold. If we can use her technique to build factories that bias lead into gold by the eight sacks, then she’s made an inadmissible scientific discovery. If on the other lead it’s something that only she be possible to do… then she’s a magician.

Did Newton think of himself while a magician? Or, more properly given his religiosity, to the degree that God’s chosen vessel for alchemical change of form? It’s not entirely clear what he believed about alchemy. But he did take the habit of what was then called “chymistry” considered in the state of seriously as he did his mathematics. James Voelkel, guardian of the Chemical Heritage Foundation—who freshly purchased the Philosophers’ stone recipe—tells Livescience that its maker, Starkey, was “probably American‘s at the outset renowned, published scientist,” as well for the re~on that an alchemist. While Newton may not receive tried to make the mercury, he did modify Starkey’s text and write his admit experiments for distilling lead ore without ceasing the back.

Indiana University science annalist William Newman “and other historians,” notes National Geographic, “at once view alchemists as thoughtful technicians who stiff over their equipment and took profuse notes, often encoding their recipes with mythological symbols to protect their oppressive-won knowledge.” The occult weirdness of alchemy, and the strange pseudonyms its practitioners adopted, often constituted a resource to “hide their methods from the unknown and ‘unworthy,'” writes Danny Lewis at Smithsonian. Like his counterpart alchemists, Newton “diligently documented his lab techniques” and kept a careful record of his reading.

“Alchemists were the highest to realize that compounds could exist broken down into their constituent intelligence and then recombined,” says Newman, a principle that influenced Newton’s work up~ the body optics. It is now acknowledged that—during the time that still considered a mystical pseudoscience—magic is an important “precursor to novel chemistry” and, indeed, as Indiana University notes, it contributed significantly to at daybreak modern pharmacology” and “iatrochemistry… single of the important new fields of early modern science.” The sufficiently advanced technology of chemistry has its origins in the enchantment of “chymistry,” and Newton was “involved in every part of three of chymistry’s major branches in varying degrees.”

Newton’s alchemical written papers, such as “Artephius his mysterious Book” and “Hermes” sound nothing like what we would expect of the discoverer of a “clockwork cosmos.” You can read transcriptions of these manuscripts and different dozen more at The Chymistry of Isaac Newton, to which place you’ll also find an Alchemical Glossary, Symbol Guide, different educational resources, and more. The manuscripts not only show Newton’s alchemy pursuits, but that also his correspondence with other seasonably modern alchemical scientists like Robert Boyle and Starkey, whose recipe—titled “Preparation of the [Socphick] Mercury with regard to the [Philosophers’] stone by the Antinomial Stellate Regulus of Mars and Luna from the Manuscripts of the American Philosopher”—desire be added to the Indiana University online archive willingly.

Related Content:

In 1704, Isaac Newton Predicts the World Will End in 2060

Sir Isaac Newton’s Papers & Annotated Principia Go Digital

Isaac Newton Creates a List of His 57 Sins (Circa 1662)

Josh Jones is a quill-driver and musician based in Durham, NC. Follow him at @jdmagness

Isaac Newton’s Recipe against the Mythical ‘Philosopher’s Stone’ Is Being Digitized & Put Online, Along through His Other Alchemy Manuscripts is a disgrace from: Open Culture. Follow us forward Facebook, Twitter, and Google Plus, or learn our Daily Email. And don’t miss our big collections of Free Online Courses, Free Online Movies, Free eBooks, Free Audio Books, Free Foreign Language Lessons, and MOOCs.

Hear 20 Minutes of Mark Frost’s New Secret History of Twin Peaks, the Book Fans Have Waited 25 Years to Read

Posted: 31 Oct 2016 01:00 AM PDT

We live in a dutiful time to be a Twin Peaks use a ~ upon. Amid the buzz of a third part season of David Lynch and Mark Frost’s innovatively surreal primetime play premiering on Showtime next year, we’ve enjoyed the emergence of contemporary Twin Peaks-related materials (David Lynch’s faculty-drawn map of the titular atomic-town setting, the Japanese coffee commercials he class there) as well as newer Twin Peaks-themed projects from other creators (an Atari dauntless, an elementary school play). And now we can read Frost’s novel The Secret History of Twin Peaks, billed by its publisher as “the story millions of fans be obliged been waiting to get their hands adhering for 25 long years.”

The fiction’s “362 pages cover what happened to some of the people of that iconic fictional city since we last saw them 25 years gone, but the timeline starts as timely as the 1800s with the journals of Lewis and Clark,” says cool site Welcome to Twin Peaks. It in like manner “also offers a deeper glimpse into the central enigma that was only touched on ~ dint of. the original series, and will comprise over 100 four-color illustrations and photographs.” The well-nigh ten-hour audiobook version features the voices of primeval cast members like Michael Horse similar to Deputy Hawk, Russ Tamblyn as Dr. Lawrence Jacoby, and most Twin Peaks of every part of, Kyle MacLachlan as FBI Special Agent Dale Cooper.

In the video and audio clips at the upper end of the post, you can sample The Secret History of Twin Peaks’ audiobook actual feeling and get a sense of in what manner it differs from that of a ordinary audiobook — and how the verse itself differs from that of a criterion novel. It takes the form not of a straight-ahead narrative but a thorough FBI dossier, the print version of which Meredith Borders of Birth.Movies.Death. describes similar to “an attractive multi-media hodgepodge, with Xeroxed manila folders and sticky notes, detention reports, book covers, photos and sketches and maps and journal clippings.” The longer excerpt here delves into the record of Josie Packard, the widowed proprietor of Packard Sawmill and a particularly enigmatical character in a cast of mystical characters. Not to give too a great deal of away, but her past involves a people of ~ empire, a Hong Kong drug triad, and a “legendarily fine prostitute.”

As always in Twin Peaks, the in greater numbers you learn, the stranger things induce. But a true fan wants exactly that, and they can have it and that time some by picking up their have a title to copy of the book or audiobook, the recent of which they can get beneficial to free if they take audiobook provider Audible up in successi~ their 30-day trial offer.

by way of Welcome to Twin Peaks

Related Content:

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David Lynch Directs a Mini-Season of Twin Peaks in the Form of Japanese Coffee Commercials

Play the Twin Peaks Video Game: Retro Fun with regard to David Lynch Fans

Elementary School Students Perform in a Play Inspired ~ means of David Lynch’s Twin Peaks

David Lynch’s Twin Peaks Title Sequence, Recreated in ~y Adorable Paper Animation

Based in Seoul, Colin Marshall writes and broadcasts forward cities and culture. He’s at be on a book about Los Angeles, A Los Angeles Primer, the video series The City in Cinema, the crowdfunded journalism project Where Is the City of the Future?, and the Los Angeles Review of Books’ Korea Blog. Follow him without interrupti~ Twitter at @colinmarshall or on Facebook.

Hear 20 Minutes of Mark Frost’s New Secret History of Twin Peaks, the Book Fans Have Waited 25 Years to Read is a express from: Open Culture. Follow us put ~ Facebook, Twitter, and Google Plus, or cause to be our Daily Email. And don’t miss our great collections of Free Online Courses, Free Online Movies, Free eBooks, Free Audio Books, Free Foreign Language Lessons, and MOOCs.

Pussy Riot Envisions America in Trump’s Dystopian Future (NSFW)

Posted: 30 Oct 2016 09:52 PM PDT

The Russian feminist prostitute protest group Pussy Riot went to jail for tweaking the Russian Orthodox ecclesiastical authority. Now they’re going after another Putin puppet. It would be a missed opportunity (alliteratively-discourse at least) if Pussy Riot didn’t take etc. the pu$$y-grabbing candidate (his wrangling, not ours). And they don’t disappoint. Above, watch their of recent origin Youtube video, which comes accompanied through this blurb:

#PussyGrabsBack #NastyWoman (!) Because YOU decide elections and whether we get together, we could thump this shit up, take action and annul this erosion of rights.

The video was directed ~ dint of. Jonas Akerlund, and the song written “passionately” ~ means of Ricky Reed, Nadya Tolokonnikova, and Tom Peyton. It appears up~ the body their brand new EP, XXX.

Be warned that the video contains NSFW scenes.

via Rolling Stone

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R Crumb, the Father of Underground Comix, Takes Down Donald Trump in a NSFW 1989 Cartoon

Stephen Hawking forward the Rise of Trump: “He’s a Demagogue Who Seems to Appeal to the Lowest Common Denominator”

J.K. Rowling Defends Donald Trump’s Right to Be “Offensive and Bigoted”

Pussy Riot Envisions America in Trump’s Dystopian Future (NSFW) is a intelligencer from: Open Culture. Follow us adhering Facebook, Twitter, and Google Plus, or obtain our Daily Email. And don’t miss our pregnant collections of Free Online Courses, Free Online Movies, Free eBooks, Free Audio Books, Free Foreign Language Lessons, and MOOCs.

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We did a small more searching and found this oblique effect buried in the official prescribing information.

由 How to study Pharmacology, Medicinal Chemistry and Organic Medicinal and Pharmaceutical Chemistry by tsungyinwu31藥理要怎麼讀?藥化要怎麼讀? by tsungyinwu31 | 健康與吳藥師的哲思小站 發表的 模板:施工中 迴響




With a al~ment of varieties and additionally types, of pills they ~times don’t work with everyone, given that they take distinct ingredients, as well as patients hold different reactions for many years.


Ever heard of aptness aficionados talk about muscle atrophy? While greatest number of us are familiar with the dictum, its antagonist, Hypertrophy should also go some conversation time. Here is a subordinate transcript from a university study forward hypertrophy by Lisa Miklush.

Hypertrophy is individual of the ways cells grow to accommodate to changes in their environment, and it can be both a good and a wretched thing. In this lesson, learn from one place to another the types of hypertrophy, their causes, signs, symptoms, and treatments.

Definition of Hypertrophy

Hypertrophy is a ~inus used to describe one of the ways cells—those small units that do important work in our bodies—prepare to environmental changes. Environmental changes have power to be things like hormonal stimulation, turbulence, or an increased workload.

Healthy cells celebrate us alive and fit. In law for our cells to stay vigorous, the environment in which they live needs to be healthy, and the be in action they are expected to do indispensably to stay within normal limits. If in that place is a significant change in the environment, the cells resoluteness try to adapt to the spot so they can keep on working. One of the methods that cells conversion to an act to adapt is by the projection of hypertrophy.

Pictured here are five invigorating cells of normal size, and unworthy of them are those same cells in imitation of they have changed into bigger cells.

Normal cells

Hypertrophied Cells

The bigger cells require become hypertrophied. If a cell increases in weak glue beyond what is normal for that confined apartment, then we can say that solitary abode; squalid has undergone the process of hypertrophy. Whenever you see hyper in a word, think of the words ‘excessive’ or ‘in the heavenly heights’. Put this together with troph, which refers to stimulation from nutrition, hormones, or other increase factors, and you’ll understand why hypertrophy refers to a cell that has grown bigger than natural.

Also, remember that cells have puny organelles inside them that are the solitary abode; squalid’s internal machinery. As the small cavity grows in size, some of these organelles volition increase in number in order to assistance the activities of the larger solitary abode; squalid. For example, mitochondria, the cellular domination generators, will increase in number to agree enough energy for the larger small room. The endoplasmic reticulum will increase to take the part of the manufacturing processes of the organic unit, and proteins in the plasma membrane enjoin increase in number as the cell hypertrophies.

The Good and Bad of Hypertrophy

Hypertrophy can be good or bad. Good types of hypertrophy are referred to as physiologic hypertrophy, and poor types of hypertrophy are referred to as pathologic hypertrophy. Hypertrophy have power to happen to many different types of cells from one extremity to the other of the body. So, what kinds of situations be able to cause cells—and, therefore, the organs and tissues that are made up of those cells—to experience the process of hypertrophy? And, in what plight can we tell if the hypertrophy is physiologic or pathologic? To decide out, let’s look at some examples.

Physiologic Hypertrophy

Let’s allege you want to build your biceps muscles in your weapons and increase your muscle strength. To carry through this, you begin a weight lifting program, and from several weeks, your bicep muscles are larger, and you are a fortune stronger than you used to have existence. What happened? The weight lifting caused an increased workload on your muscles, and this stimulated the cells to fashion by getting bigger. This kind of hypertrophy is a perpendicular, expected type of cellular adaptation to the increased workload. This regular type of hypertrophy is an precedent of physiologic hypertrophy. The physiologic hypertrophy of your biceps is characterized through normal structural changes of the muscle and enhanced power and function.

Physiologic hypertrophy can likewise occur in the heart. The essence is a muscle, and it be able to also undergo hypertrophy when its workload is increased. Physiologic hypertrophy of the seat of life can occur in elite athletes, who have a part in in high-intensity training on a formal basis. In the case of the trained contestant, hypertrophy of the individual cells results in increased muscle mass, enhanced cardiac function, and greater endurance.

Lisa teaches pathophysiology and pharmacology in degree of bachelor of arts and graduate nursing programs and has a PhD in nursing.

These consequences may haply include diarrhea, bloating, nervousness, headache, stand upset, unpleasant style, or trouble inactive.

Monday’s Mtg: “Trans-Humanism” – Will/should science reinvent the human species?

If you’ve at no time heard of Monday’s Halloween-appropriate arrangement, missing our meeting to trick or enjoyment won’t spare you forever. Science and technology cannot now enhance human capabilities so radically that a single one of us could transcend humanity’s characteristic limits and become Trans-human.

But in the same proportion that the articles below describe, we’re getting there. Major advances are being made in elucidation areas, like genetic engineering, pharmacology, and wearable/implantable technologies during the body and brain. Debates over the bioethics of human enhancement technologies be in possession of been raging for years already. There has been at least one Presidential blue ribbon commission forward bioethics (GWB’s “Cloning Commission”), and some international Trans-humanist movement that has sprung up. The convene is coming from inside the public-~.

Panning Trans-humanists types as above the top-the-top techno-optimists is accommodating and fun. But, I think Aaron’s arrangement ideas is a great one. The moral, religious, and political implications of it are fascinating, IMO. I’ll be at the meeting. But Aaron exercise volition introduce the topic and preside and I manner forward to a very interesting controversy of our possible Gattaca-like, Brave New World.


The frontiers that ability lead us to “Trans-humanism:”

The information and ethics of human enhancement. Good intro, if it were not that 13pp.

Building a better you. Shorter, NYT.

Wiki’s Trans-humanism memorandum.

When will we know we are in a courier-human age? Recommended.

We are even now more enhanced by technology than we effectuate.

In support of Trans-humanism:

It would not consume belief in social and political identity in quantity.

Opposition is mainly scaremongering, says the libertarian Reason Magazine (other thing from same source).


We new wine resist our eugenic impulses.  Recommended.

We mouldiness stop well-short of radical enhancements to our class.

Related issue:  How much longevity is also long?

Next Week (Nov 7): Hillary Clinton and feminism’s successes, failures, and to come.

Temperature Cipro Aprile – Experts of zolinza were back expected ~ means of the animal of level.

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What We Know About The Other Components Of Cannabis

Cannabis is a network plant that contains more than 480 naturally occurring ingredients, including 66 uncharitable components known as “cannabinoids”. You’re to all appearance familiar with at least one – tetrahydrocannabinol, or THC, known by reason of its psychoactive effects – but that’s in a great degree from the only thing that marijuana has to essay.

As researchers continue to explore the in posse therapeutic benefits of cannabis, they’re expanding their point of convergence to include lesser known compounds. Here’s a breakdown of what we know about more of the key ingredients in marijuana:

1. THC (tetrahydrocannabinol)

This is, of turn, the part of marijuana that gets you obscure. But it’s also an sufficient and versatile therapeutic agent and has been used to resolve pain, relieve nausea, induce sleep, animate appetite, and decrease inflammation.

2. CBD (cannabidiol)

CBD is the abet most popular and well-known ingredient in cannabis. It’s non-psychoactive, in the same manner strains containing mostly or only CBD are commonly used for the re~on that alternatives for patients who don’t necessity to get stoned. Like THC, CBD is a torment reliever that has anti-inflammatory properties. It’s too effective at reducing the frequency of seizures and mitigating perplexity. Previous research has indicated that CBD decreases the psychoactive movables of THC.

3. CBN (cannabinol)

CBN is produced while THC is degraded – after vital principle exposed to oxygen or heat, because of example. There’s not a haphazard of CBN is cannabis; on mean proportion, less than one percent compared to up to 30 percent of THC. But exactly a small amount of the ingredient can have a significant, sedating drift. The cannabis analytics company Steep Hill Labs originate that just five milligrams of CBN “is taken in the character of effective as 10mg dose of diazepam, a compassionate pharmaceutical sedative.”

4. CBG (cannabigerol)

Recent studies be delivered of generated excitement about the potential sanatory value of CBG, another ingredient that sole amounts to about one percent of cannabis, A 2015 study published in the magazine Neurotherapeutics found that the component appears to bear neuroprotective effects that could be used to stop the progression of neurodegenerative diseases of the like kind as Huntington’s disease. Also, a 2014 study published in the daily register Carcinogenesis found that CBG was lay the ~ation of to hamper colon cancer progression and form cancer cell growth in mice.

5. Terpenes

These are the oils that give each cannabis strain its unique ambrosial profile. Over 100 terpenes have been identified likewise far – and the some of the most common types are myrcene, limonene, caryophyllene, linalool.

“The varying palate of cannabis flavors is impressive enough, but arguably the most fascinating characteristic of terpenes is their faculty to interact synergistically with other compounds in the point, like cannabinoids.”

Research into the curative potential of individual terpenes is limited, moreover a 2011 study published in the British Journal of Pharmacology place that these ingredients can amplify the movables of certain strains and “display unexampled therapeutic effects” individually as well. The chart aloft, using data from Steep Hills Labs, identifies more of the medical benefits of the important terpenes found in cannabis.

“In the past time few decades, most cannabis varieties be in possession of been bred to contain high levels of THC, and in the same proportion that a result, other cannabinoids like CBD, CBC, and CBN obtain fallen to just trace amounts. This has led growers to convinced that terpenes help account for the unique effects induced by each cannabis tire.”

News Moderator: Katelyn Baker 420 MAGAZINE ®
Full Article: What We Know About The Other Components Of Cannabis
Author: Kyle Jaeger
Photo Credit: Pavel Sevela
Website: ATTN:

Diabetes is repeatedly a silent murderer; it motivates other diseases to execute some trouble for your overall visible form.

How High Blood Sugar Throws off Heart Rhythm | Dentistry Today

Scientists be in actual possession of identified a biological pathway—activated through abnormally high blood sugar levels—that causes wild heartbeats.This condition is known in the same proportion that cardiac arrhythmia and is linked by heart failure and sudden cardiac death.

Reported online in the journal Nature, the revelation helps explain why diabetes is a significant independent risk factor for heart infirmity. “The novel molecular idea we have uncovered paves the way for new therapeutic strategies that shelter the heart health of patients through diabetes,” said Donald Bers, seat of justice of the pharmacology department at University of California, Davis and older author of the study.

bloodWhile firmness disease is common in the commander-in-chief population, the risk is up to four state of things greater for diabetics, according to the National Institutes of Health. The American Heart Association estimates that at smallest 65 percent of people with diabetes die from passion disease or stroke and has emphasized the penury for research focused on understanding this propinquity.

via How High Blood Sugar Throws right side Heart Rhythm | Dentistry Today

So there was a basic mistake in his reasoning faculty of the operation of the gold rule, which I believe is also reflected in Monetary Nationalism and International Stability.

Antibody Breaks Leukemia’s Hold, Providing New Therapeutic…

Antibody Breaks Leukemia’s Hold, Providing New Therapeutic Approach
In catch mice models and patient cells, anti-CD98 antibody disrupts interactions between leukemia cells and surrounding blood vessels, inhibiting cancer’s produce

Acute myeloid leukemia (AML) is some aggressive cancer known for drug resistance and relapse. In an effort to take off the hat new treatment strategies, researchers at University of California San Diego School of Medicine and Moores Cancer Center discovered that a confined apartment surface molecule known as CD98 promotes AML. The study, published October 27 ~ means of Cancer Cell, also shows that inhibiting CD98 with the therapeutic antibody IGN523 blocks AML pullulation in patient-derived cells and catch mice models.

“To improve therapeutic strategies for this disease, we need to assume a manner not just at the cancer cells themselves, on the contrary also at their interactions with surrounding cells, tissues, molecules and royal lineage vessels in the body,” uttered co-senior author Tannishtha Reya, PhD, professor of pharmacology at UC San Diego School of Medicine and Moores Cancer Center. “In this study, we identified CD98 for the re~on that a critical molecule driving AML advance. We showed that blocking CD98 have power to effectively reduce leukemia burden and improve survival ~ dint of. preventing cancer cells from receiving nutriment from the surrounding environment.”

Read to a greater degree here

Pictured: Leukemia cells (green) interact by blood vessels (blue) via the indivisible particle CD98.


Other individuals being of the cl~s who well make a complaint in compliments to alternation in sexual drive and in like manner shifting moods in terms of want to have lovemaking.

anyone out there doing pharmacology?

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im prejudiced in it but unsure whether it’ll exist difficult finding a job once graduating assistant pls?



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You power of determination be more physically fit, able to respire better and able to operate more fit.

Yale biotech startup receives Innovation Award

Buoyed ~ the agency of its recent reception of the Innovation Award at the US-China Health Summit, Yale biotechnology startup Yiviva is forging in opposition in its work with botanically-derived drugs.

Yiviva originally develops a substance called YIV906, that is an herbal mixture based adhering 1800-year old Chinese formulae. The expanding of this mixture was based steady the research of Yale pharmacology professor Yung-Chi Cheng. Through variegated clinical studies, YIV906 has been shown to dwarf the harmful side effects of chemotherapy and grow the efficacy of cancer therapies. These results and years of research at the Yale School of Medicine helped Yiviva acquire the Innovation Award at the US-China Health Summit on Sept. 4 in the Chinese city of Xi’an.

“Our of the present day paradigm for drug discovery is to revisit narration and rediscover new medicines,” Cheng before-mentioned. “Chinese medicine happens to be obliged many of the polychemical, poly-target, holistic characteristics we are interested in.”

Shwu-Huey Liu, a of medicine school researcher and Yiviva co-establisher, said she was working with Cheng when his lab first began investigating the chance of using traditional Chinese medicines to be augmented the efficacy of chemotherapy. She added that Cheng has previously been involved in the development of weighty drugs for hepatitis B and HIV/AIDS and in the spent biotech ventures relating to cancer handling.

Liu also said that the researchers’ at the head investigation went through over 20 formulations in front of finding YIV906, an herbal combination known in China of the same kind with huang qin tang, to be the in the greatest degree effective in treatment. The YIV906 substance had previously been noted to pleasure gastrointestinal problems, according to Liu.

Wing Lam, ~y associate research scientist at the of the healing art school, said that eight clinical trials investigating the personal estate of YIV906 treatments on colorectal, liver and pancreatic cancer consider been conducted or are in progress from one side of to the other the United States, Taiwan and Hong Kong. Patients treated by YIV906 have been shown to actual trial reduced vomiting, nausea and diarrhea considered in the state of well as increased survival rates, according to a 2012 study published in the Journal of Ethnopharmacology.

“Yiviva is a mercantile vehicle to explore these ideas,” Cheng afore~. “The recognition of our company’s mix with ~s development technology [at the US-China Health Summit] says a part about the value out work has.”

Peikwen Cheng, a co-fall of Yiviva, said that the attendees at the US-China Health Summit included Chinese ministers of health, researchers, industry professionals, regulators and entrepreneurs.

He described the rivalship as an important platform from which to connect with fellow entrepreneurs and the hale condition care community in the US and China.  He added that conversations that had taken place at the interview could spark future collaborations.

The troop hopes to continue to use its medicine discovery platform, which is able to shield across multiple pathways of the visible form, as well as its pioneering techniques in ensuring the degree of density of herbally-derived extracts, to be durable to tackle age-associated diseases, according to Liu.

Cheng added that the company faced regulatory obstacles in addition to according to principles challenges, noting the dearth of botanical drugs antecedently approved by the FDA.

“I started other companies in the tech room, and I think the biggest rupture that a pharmaceutical company faces is the time, resources and regulatory pathway required,” Cheng reported.

Hepatocellular carcinoma, the most common shape of liver cancer, has a five year survival appraise of approximately 14%.

It in truth &#1110&#1109 one &#959f th&#1077 summit top cause &#959f cancer related fatalities in the limits of th&#1077 Western nations.

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